Product ID:3-ISOCYANOTOBENZONITRILE, 223860
MSDS Date:01/14/1994
FSC:6810
NIIN:00N055285
MSDS Number: CDMRZ

ICN BIOMEDICALS

1263 S CHILLICOTHE RD
AURORA, OH 44202
US

Emergency Phone: 800-424-9300 (CHEMTREC)

Info Phone: 216-562-1500

Preparer: RL

Cage: IO030

ICN BIOMEDICALS INC

28050 CLEVELAND, OH 44128-0250 US

Telephone: 216-831-3000

Cage: IO030

M-ISOCYANATOBENZONITRILE

CAS: 16413-26-6

OSHA PEL N/K

ACGIH TLV: N/K

ENZYMES ARE NOT FOUND IN MAMMALIAN TISS, HUMAN

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ENZYMES CAPABLE OF EFFECTING CYANIDE RELEASE RSLTG IN

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MUCH AS 40 TIMES MORE TOX BY ORAL RTE AS COMPARED

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LAETRILE, & THIS ALLEGED ANTICANCER DRUG HAS ALSO

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THAT MAY ALSO CAUSE CYANIDE POIS IN OVERDOSE IS THE

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NITROPRUSSIDE. ALTHOUGH NITROPRUSSIDE IS RELATED

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INTO ERYTHROCYTES AND REACTS WITH HEMOGLOBIN TO

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FOR NITROPRUSSIDE APPEARS TO BE QUITE LARGE. CYANIDE

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SILVER & METAL POLISHES, PHOTOGRAPHIC SOLUTIONS, &

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CYANIDE CAN ALSO BE READILY PURCHASED FROM CHEM

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SKIN, MUC MEM, & INHAL, ALTHOUGH ALKALI SALTS OF

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IN MIN/HRS DEPENDING ON RTE OF EXPOS. INHAL OF TOX

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SODIUM NITROPRUSSIDE & APRICOT SEEDS HAVE ALSO

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IS CONSIDERED TOX. LETHAL CASES HAVE USUALLY HAD

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PRDCE BITTER, ALMOND ODOR ON BRTH OF PATIENT;

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ABLE TO DISCERN THIS CHARACT ODOR. TYPICALLY,

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OF SALIVATION, NAUS W/OUT VOMIT, ANXIETY, CONFUSN,

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OPISTHOTONOS, PARAL, COMA, CARD ARRHYS, & TRANSIENT

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BRADYCARDIA IS A COMMON FINDING, BUT IN MOST CASES

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PHASE IS CONSIDERED TO BE CHARACT OF CYANIDE POIS.

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PHYSIOLOGICALLY, INHIBITING TISS OXIDATION & CAUSING

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HYDROCYANIC ACID; NITRILES ARE GEN CONSIDERED

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NON-VOLAT CYANIDE SALTS APPEAR TO BE RELATIVELY

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CARE IS TAKEN TO PVNT FORM OF HYDROCYANIC ACID. FOR

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LD50 LC50 Mixture:NONE SPECIFIED BY MANUFACTURER.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE:MOD TO SEV ERYTHEMA (REDNESS) &
MOD EDEMA (RAISED SKIN). CYANIDE:DIRECTLY STIMULATES CHEMORECEPTORS
OF CAROTID & AORTIC BODIES W/RESULTANT HYPERPNEA. CARD
IRREGULARITIES ARE OFTEN NOTED, BUT HEA RT INVARIABLY OUTLASTS
RESPS. DEATH IS DUE TO RESP ARREST OF CENTRAL ORIGIN. IT CAN OCCUR
W/IN SECONDS/(EFTS OF OVEREXP)
Explanation of Carcinogenicity:NOT RELEVANT.
Effects of Overexposure:HLTH HAZ:MIN OF INHAL OF HIGH CONCS OF HYDROGEN
CYANIDE GAS. BECAUSE OF SLOWER ABSORPTION, DEATH MAY BE MORE
DELAYED AFTER INGEST OF CYANIDE SALTS, BUT CRITICAL EVENTS STILL
OCCUR W/IN FIRST HR. TWO O THER SOURCES OF CYANIDE HAVE BEEN
RESPONSIBLE FOR HUMAN POIS. ONE IS AMYGDALIN, A CYANOGENIC
GLYCOSIDE FOUND IN(SUP DAT)
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

First Aid:SKIN: REMOVE CONTAM CLTHG, RINSE LIBERALLY W/SOAP & WATER FOR
CONSIDERABLE PERIOD. CALL MD. INGEST: RINSE MOUTH SEVERAL TIMES
W/WATER, DO NOT SWALLOW. CALL MD/TAKE PATIENT TO HOSPITAL. EYES:
RINSE LIB ERALLY W/WATER FOR AT LEAST 15 MIN. CALL MD/TAKE PATIENT
TO HOSPITAL. INHAL: TAKE PATIENT INTO FRESH AIR & ALLOW TO REST.
CALL MD/TAKE PATIENT TO HOSPITAL.

Extinguishing Media:CARBON DIOXIDE, DRY CHEMICAL, FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SCBA & FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:MOD, BY CHEM RXN W/HEAT, MOISTURE, ACID.
MANY CYANIDES EVOLVE HYDROCYANIC ACID RATHER EASILY. THIS IS A FLAM
GAS & IS HIGHLY TOX. CARBON DIOXIDE FROM (SUP DAT)

Spill Release Procedures:ABSORB THE LIQUID IN DRY SAND, DIATONITE,
VERMICULITE, ETC, SHOVEL THE MIXTYRE INTO PLASTIC BAGS AND REMOVE
TO THE CENTRAL DEPOT FOR CHEMICAL WASTE.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

Handling and Storage Precautions:STORE AT ROOM TEMPERATURE.
Other Precautions:SWEEP INTO SUITABLE CONTAINER FOR DISPOSAL.

Respiratory Protection:USE NIOSH APPROVED RESPIRATOR APPROPRIATE FOR
EXPOSURE OF CONCERN .
Ventilation:LOCAL EXHAUST REQUIRED.
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:ANSI APPRVD CHEM WORKERS GOGGLES .
Other Protective Equipment:EMERGENCY EYEWASH AND DELUGE SHOWER MEETING
ANSI DESIGN CRITERIA .
Work Hygienic Practices:NONE SPECIFIED BY MANUFACTURER.
Supplemental Safety and Health
EXPLO HAZ: AIR IS SUFFICIENTLY ACIDIC TO LIBERATE HYDROCYANIC ACID FROM
CYANIDE SOLNS. EFTS OF OVEREXP: APRICOT, PEACH & SIMILAR FRUIT PITS
& IN SWEET ALMONDS. AMYGDALIN IS CHEM COMBINATION OF GLUCOSE ,
BENZALDEHYDE, & CYANIDE FROM WHICH LATTER CAN BE RELEASED BY ACTION
OF B-GLUCOSIDASE/EMULSIN. ALTHOUGH THESE (ING 2)

Solubility in Water:INSOLUBLE
Appearance and Odor:LIQUID

Stability Indicator/Materials to Avoid:YES
STRONG ACIDS, STRONG OXIDIZING AGENTS. VIOLENT REACTION W/F*2, MG,
NITRATES, HNO*3.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:TOXIC FUMES OF CN-, NO*X.

Waste Disposal Methods:INCINERATE OR LANDFILL AS COMPLIES WITH STATE
AND LOCAL LAWS. DISPOSE OF IN ACCORDANCE WITH LOCAL, STATE AND
FEDERAL REGULATIONS .

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.